Technology Transfers

We represent established and reliable overseas companies for both classical fermentation product technologies and for rDNA therapeutic protein technologies. These companies are expert in their respective areas.

The rDNA technologies are designed for expressing recombinant native human proteins, having very high value as biopharmaceuticals. Having the knowledge of rDNA technology, we are able to suggest, guide, take you through the technology transfer process and further assist you in technology implementation if desired.

Some of the salient features of the rDNA technologies that we offer are:

Wide range of products
High yielding r-DNA clones.
Cost effective purification process
Training at technology provider's facility abroad
More than 99% purity of final protein
Back-up and support for implementation.

Brief Description Of rDNA Technology Transfer Package

1. Manufacturing	2. Biosynthesis of the protein substance
General. Construction of the plasmid expressing of the protein. DNA sequence. Expression of the protein in E.coli.	Fermentation process. Inoculum. Seed fermentor. Production fermentor. Fermentor Harvest. Cell disruption. Water Washes.

3. Purification of the protein from inclusion bodies	4. Detailed characterization of the protein
Dissolution of the protein inclusion bodies. Dilution and refolding of the protein. Clarification and concentration. Enzymatic removal of the N-terminal methionine (if needed). Purification of the protein by preparative RP-HPLC (if needed). Purification of the protein by ion-exchange Chromatography (if needed). Dialysis and Lyophilization.	Polyacrylamide gel electrophoresis. UV spectroscopy. N-terminal amino acid sequence determination. Analytical reversed-phase HPLC. Biological activity in-vitro.

5. Characterization of impurities
Endotoxin content by LAL.

The rDNA Technologies that we offer are:

Interferon Alpha 2a & 2b, Interferon Beta, Interleukins, G-CSF, GM-CSF, EGF, HGH, EPO, Insulin and many others.

We also offer classical fermentation technologies for

1. Cyclosporin A,
2. Clavulanic acid,
3. Erythromycin,
4. Hyaluronic acid (HA),
5. Vancomycin,
6. Lovastatin,
7. Rapamycin,

8. Natamycin,
9. Itaconic Acid,
10. Shikimic Acid,
11. Vitamin B12,
12. Glutathione,
13. Carotin,
14. Xanthan .
and many more....

Contract Manufacturing

For overseas clients, India is a major player in pharma generics and also for off-patent biotech rDNA protein manufacturing.

Having excellent infrastructure which complies with the stringent GMP standards and with competent people to handle the job the only issue is the cost, which by all western standards is attractively low.

We being in the core area of Biotechnology and Pharmaceuticals are associated with reliable companies who carry out manufacturing for pharma and biotech industries.

We provide you the right partner for outsourcing the manufacturing. After due evaluation of the facility and staff, you may enter into contract with these companies for your products. If you require monitoring the process, time to time and also performing quality audits, we can extend the necessary support to you.

We provide contract manufacturing for non-sterile dosages, including powders, capsules, tablets, ointments and liquid filling.

We also offer contract manufacturing for sterile dosage forms.

As regards fermentation based products, our range covers from small scale fermentations of 10 L to 50KL.

We have excellent tie-ups for rDNA manufacturing including the DSP.

Our Services
Biopharmaceutical Services	Project Feasibility Reports	Clean Room Technology	Microbiological Evaluation & Testing
Technology Transfers	Contract Manufacturing	Facility Design	Laboratory Design & Furniture
Biopharmaceutical Technology Development		Turnkey Projects